Table 1 Summary of preclinical publications reviewed
From: Systematic review of cognitive impairment and brain insult after mechanical ventilation
| Publication | Population | Mechanical ventilation/experimental model | Neuro-inflammation/cellular apoptosis observed after mechanical ventilation | Low cognitive scores measured after mechanical ventilation | Brain area(s) studied |
|---|---|---|---|---|---|
| 2005, Fries et al. [14] |
Pigs (n = 14) | Yes/tidal volume 10 ml/kg, lung injury (by reduced inspired oxygen and by bronchoalveolar lavage) | Yes | – | Hippocampus |
| 2011, Quilez et al. [15] |
Mice (n = 24) | Yes/low tidal volume (8 ml/kg), high tidal volume (30 ml/kg), and spontaneously breathing | Yes | – | Hippocampus, retrosplenial cortex, thalamus, central amygdala, paraventricular nuclei, and supraoptic nuclei |
| 2011, Bickenbach et al. [16] |
Pigs (n = 10) | Yes/tidal volume 10 ml/kg, lung injury (by oleic acid and by bronchoalveolar lavage) | Yes | Yes | Hippocampus |
| 2013, Gonzalez-Lopez et al. [4] |
Mice (n = 127) | Yes/low peak inspiratory pressure (12 cmH2O) and high peak inspiratory pressure (20 cmH2O) | Yes | – | Hippocampus |
| 2015, Chen et al. [5] |
Mice (n = 86) | Yes/peak inspiratory pressure (15 cmH2O) (1 h, 3 h and 6 h), and spontaneously breathing | Yes | Yes | Hippocampus |
| 2016, Chen et al. [6] |
Mice (n = 72) | Yes/peak inspiratory pressure (15 cmH2O) (1 h, 3 h and 6 h), and spontaneously breathing | Yes | Yes | Hippocampus |
| 2018, Kamuf et al. [13] |
Pigs (n = 20) | Yes/tidal volume 7 ml/kg, lung injury (by oleic acid and by bronchoalveolar lavage) | Yes | – | Hippocampus |
| 2019, Lopez-Aguilar et al. [17] |
Pigs (n = 17) | Yes/tidal volume 10 ml/kg, three different head positions (+ 30°, + 5°, − 30°) | Yes | – | Hippocampus |
| 2019, Gonzalez-Lopez et al. [18] |
Mice (n = 32) | Yes/high tidal volume (20–30 ml/kg) and spontaneously breathing | Yes | – | Hippocampus |